Book

Description

Cancer is an abnormal growth of cells caused by multiple changes in gene expression leading to dysregulated balance of cell proliferation and cell death and ultimately evolving into a population of cells that can invade tissues and metastasize to distant sites, causing significant morbidity. Basically, dysregulation or mutations of the components of the signalling molecules can promote tumorigenesis. Singling pathways include MAPK, PI3K/Akt, mTOR, Wnt/β-catenin, STAT3, FOXO, Notch, Mitophagy, Hedghog were few examples for converting the normal cell to cancer cells. On the other hand, these signalling molecules were targeted to develop drugs against the cancer. In this book, we would like to document all the signalling pathways that were dysregulated in various cancers.